How the guts turns into bone
The determine exhibits calcium deposits within the hearts of mice (A,D) and the impact of two medicine, ARL67156 (B,E) and etidronate (C,F), in reducing the extent of calcium deposits after coronary heart harm. Credit score: Pillai and Li et al./Cell Stem Cell 2016 Connective tissue cells within the coronary heart flip into bone-producing cells in response to harm, College of California, Los Angeles scientists report November 17 in Cell Stem Cell . The invention helps clarify why some individuals who survive coronary heart injury develop irregular calcium deposits -- the primary part of bone -- within the valves or partitions of the center. The researchers additionally present that coronary heart calcification might be prevented in mice by blocking an enzyme that regulates bone mineralization with small molecules. Tissues exterior of the bones do not naturally calcify, but mineralization of organs, together with the center, blood vessels, an...